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Publications
2024
  • Banik P, Ray K, Kamps J, Chen QY, Luesch H, Winklhofer KF, Tatzelt J (2024) VCP/p97 mediates nuclear targeting of non-ER-imported prion protein to maintain proteostasis. Life Sci Alliance 2024 Apr 3; 7(6):e202302456. doi: 10.26508/lsa.202302456
  • Polido SA, Stuani C, Voigt A, Banik P, Kamps J, Bader V, Grover P, Krause LJ, Zerr I, Matschke J, Glatzel M, Winklhofer KF, Buratti E, Tatzelt J (2024) Cross seeding by prion protein inactivates TDP-43. Brain 2024 Jan 4; 147(1):240-254. doi: 10.1093/brain/awad289
2023
  • Furthmann N, Bader V, Angersbach L, Blusch A, Goel S, Sanchez-Vicente A, Krause LJ, Chaban SA, Grover P, Trinkaus VA, van Well EM, Jaugstetter M, Tschulik K, Damgaard RB, Saft C, Ellrichmann G, Gold R, Koch A, Englert B, Westenberger A, Klein C, Jungbluth L, Sachse C, Behrends C, Glatzel M, Hartl FU, Nakumara K, Christine CW, Huang EJ, Tatzelt J, Winklhofer KF (2023) NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62. Nat. Commun Dez 19, 2023. doi: 10.1038/s41467-023-44033-0
  • Ramos S, Kamps J, Pezzotti S, Winklhofer KF, Tatzelt J, Havenith M. (2023) Hydration make a difference! How to tune protein complexes between liquid-liquid and liquid-solid phase separation. Phys Chem Chem Phys 2023 Oct 16. doi: 10.1039/d3cp03299
  • Goel S, Oliva R, Jeganathan S, Bader V, Krause LJ, Kriegler S, Stender ID, Christine CW, Nakamura K, Hoffmann JE, Winter R, Tatzelt J*, Winklhofer KF*. (2023) Linear ubiquitination induces NEMO phase separation to activate NF-κB signaling. Life Sci Alliance Jan 31, 2023. doi: 10.26508/lsa.202201607
    * - corresponding author
  • Rybarski M, Mrohs D, Osenberg K, Hemmersbach M, Pfeffel K, Steinkamp J, Schmidt D, Violou K, Schäning R, Schmidtke K, Bader V, Andriske M, Bohne P, Mark MD, Winklhofer KF, Lübbert H, Zhu XR (2023) Loss of parkin causes endoplasmic reticulum calcium dyshomeostasis by upregulation of reticulocalbin 1. Eur J Neurosci 2023 Mar; 57(5):739-761. doi: 10.1111/ejn.15917
2022

  • Wu Z, Berlemann LA, Bader V, Sehr DA, Dawin E, Covallero A, Meschede J, Angersbach L, Showkat C, Michaelis JB, Münch C, Rieger B, Namgaladze D, Herrera MG, Fiesel FC, Springer W, Mendes M, Stepien J, Barkovits K, Marcus K, Sickmann A, Dittmar G, Busch KB, Riedel D, Brini M, Tatzelt J, Cali T, Winklhofer KF (2022) LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus. EMBO J. 15;41(24): e112006. doi: 10.15252/embj.2022112006

  • Junghans M, John F, Cihankaya H, Schliebs D, Winklhofer KF, Bader V, Matschke J, Theiss C, Matschke V (2022) ROS scavengers decrease γH2ax spots in motor neuronal nuclei of ALS model mice in vitro. Front Cell Neurosci. 31;16: 963169. doi: 10.3389/fncel.2022.963169

  • Meister TL, Brüggemann Y, Nocke MK, Ulrich RG, Schuhenn J, Sutter K, Gömer A, Bader V, Winklhofer KF, Broering R, Verhoye L, Meuleman P, Vondran FWR, Camuzet C, Cocquerel L, Todt D, Steinmann E (2022) A ribavirin-induced ORF2 single-nucleotide variant produces defective hepatitis E virus particles with immune decoy function. Proc Natl Acad Sci U S A. 23;119(34): e2202653119. doi: 10.1073/pnas.2202653119

  • Mueller-Buehl C, Reinhard J, Roll L, Bader V, Winklhofer KF, Faissner A (2022) Brevican, Neurocan, Tenascin-C, and Tenascin-R Act as Important Regulators of the Interplay Between Perineuronal Nets, Synaptic Integrity, Inhibitory Interneurons, and Otx2. Front Cell Dev Biol. 2;10:886527. doi: 10.3389/fcell.2022.886527

  • Krause LJ, Herrera MG, Winklhofer KF (2022) The Role of Ubiquitin in Regulating Stress Granule Dynamics. Front Physiol. 25; 13:910759. doi: 10.3389/fphys.2022.910759

2021

  • Stein J, Walkenfort B, Cihankaya H, Hasenberg M, Bader V, Winklhofer KF, Röderer P, Matschke J, Theiss C, Matschke V (2021) Increased ROS-Dependent Fission of Mitochondria Causes Abnormal Morphology of the Cell Powerhouses in a Murine Model of Amyotrophic Lateral Sclerosis. Oxid Med Cell Longev. 14;2021:6924251. doi: 10.1155/2021/6924251

  • Schlagowski AM, Knöringer K, Morlot S, Sánchez Vicente A, Flohr T, Krämer L, Boos F, Khalid N, Ahmed S, Schramm J, Murschall LM, Haberkant P, Stein F, Riemer J, Westermann B, Braun RJ, Winklhofer KF, Charvin G, Herrmann JM (2021) Increased levels of mitochondrial import factor Mia40 prevent the aggregation of polyQ proteins in the cytosol. EMBO J. 30;e107913. doi: 10.15252/embj.2021107913

  • Oliva R, Mukherjee SK, Ostermeier L, Pazurek LA, Kriegler S, Bader V, Prumbaum D, Raunser S, Winklhofer KF, Tatzelt J, Winter RHA (2021) Remodeling of the Fibrillation Pathway of α-Synuclein by Interaction with Antimicrobial Peptide LL-III. Chemistry 24. doi: 10.1002/chem.202101592

  • Kamps J, Lin YH, Oliva R, Bader V, Winter R, Winklhofer KF, Tatzelt J (2021) The N-terminal domain of the prion protein is required and sufficient for liquid-liquid phase separation: A crucial role of the Aβ-binding domain. J Biol Chem 6;297(1): 100860. doi.: 10.1016/j.jbc.2021.100860

  • Ulfig A, Bader V, Varatnitskaya M, Lupilov N, Winklhofer KF, Leichert LI (2021) Hypochlorous acid-modified human serum albumin suppresses MHC class II - dependent antigen presentation in pro-inflammatory macrophages. Redox Biol. 43:101981. doi: 10.1016/j.redox.2021.101981

  • Lei L, Wu Z, Winklhofer KF (2021) Protein quality control by the proteasome and autophagy: A regulatory role of ubiquitin and liquid-liquid phase separation. Matrix Biol. 100-101:9-22. doi: 10.1016/j.matbio.2020.11.003

  • Ingles-Prieto A, Furthmann N, Crossman SH, Tichy AM, Hoyer N, Petersen M, Zheden V, Biebl J, Reichhart E, Gyoergy A, Siekhaus DE, Soba P, Winklhofer KF, Janovjak H (2021) Optogenetic delivery of trophic signals in a genetic model of Parkinson's disease. PLoS Genet. 15;17(4):e1009479. doi: 10.1371/journal.pgen.1009479

  • Marks D, Heinen N, Bachmann L, Meermeyer S, Werner M, Gallego L, Hemmerich P, Bader V, Winklhofer KF, Schröder E, Knauer SK, Müller T (2021) Amyloid precursor protein elevates fusion of promyelocytic leukemia nuclear bodies in human hippocampal areas with high plaque load. Acta Neuropathol Commun. 13;9(1):66. doi: 10.1186/s40478-021-01174-x

  • Ahlers J, Adams EM, Bader V, Pezzotti S, Winklhofer KF, Tatzelt J, Havenith M (2021) The key role of solvent in condensation: mapping water in liquid-liquid phase-separated FUS. Biophys J. 6;120(7):1266-1275. doi: 10.1016/j.bpj.2021.01.019

2020
  • Jung S, Bader V, Natriashvili A, Koch HG, Winklhofer KF, Tatzelt J (2020) SecY-mediated quality control prevents the translocation of non-gated porins. Sci Rep. 1;10(1):16347. doi: 10.1038/s41598-020-73185-y
  • Bader V, Winklhofer KF (2020) PINK1 and Parkin: team players in stress-induced mitophagy Biol Chem. 26;401(6-7):891-899. doi: 10.1515/hsz-2020-0135

  • Duscha A, Gisevius B, Hirschberg S, Yissachar N, Stangl GI, Eilers E, Bader V, Haase S, Kaisler J, David C, Schneider R, Troisi R, Zent D, Hegelmaier T, Dokalis N, Gerstein S, Del Mare-Roumani S, Amidror S, Staszewski O, Poschmann G, Stühler K, Hirche F, Balogh A, Kempa S, Träger P, Zaiss MM, Holm JB, Massa MG, Nielsen HB, Faissner A, Lukas C, Gatermann SG, Scholz M, Przuntek H, Prinz M, Forslund SK, Winklhofer KF, Müller DN, Linker RA, Gold R, Haghikia A (2020) Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism. Cell 19;180(6):1067-1080.e16. doi: 10.1016/j.cell.2020.02.035

  • Bader V, Winklhofer KF (2020) Mitochondria at the interface between neurodegeneration and neuroinflammation. Semin Cell Dev Biol. 99, 163-171. doi: 10.1016/j.semcdb.2019.05.028

  • Meschede J, Šadić M, Furthmann N, Miedema T, Sehr DA, Müller-Rischart AK, Bader V, Berlemann LA, Pilsl A, Schlierf A, Barkovits K, Kachholz B, Rittinger K, Ikeda F, Marcus K, Schaefer L, Tatzelt J, Winklhofer KF (2020) The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC. Sci Signal. 4;13(617):eaav1256. doi: 10.1126/scisignal.aav1256

  • Dittmar G, Winklhofer KF (2020) Linear Ubiquitin Chains: Cellular Functions and Strategies for Detection and Quantification. Front Chem. 10;7:915. doi: 10.3389/fchem.2019.00915

  • Xie K, Varatnitskaya M, Maghnouj A, Bader V, Winklhofer KF, Hahn S, Leichert LI (2020) Activation leads to a significant shift in the intracellular redox homeostasis of neutrophil-like cells. Redox Biol. doi: 10.1016/j.redox.2019.101344

2019
  • Teucher M, Zhang H, Bader V, Winklhofer KF, García-Sáez AJ, Rajca A, Bleicken S, Bordignon E (2019) A new perspective on membrane-embedded Bax oligomers using DEER and bioresistant orthogonal spin labels. Sci Rep. 9(1): 13013. doi: 10.1038/s41598-019-49370-z

  • Riederer P, Berg D, Casadei N, Cheng F, Classen J, Dresel C, Jost W, Krüger R, Müller T, Reichmann H, Rieß O, Storch A, Strobel S, van Eimeren T, Völker HU, Winklhofer KF, Wüllner U, Zunke F, Monoranu CM (2019) α-Synuclein in Parkinson's disease: causal or bystander? J. Neural Transm (Vienna). 126(7): 815-840. doi: 10.1007/s00702-019-02025-9

  • Ceballos J, Schwalfenberg M, Karageorgis G, Reckzeh ES, Sievers S, Ostermann C, Pahl A, Sellstedt M, Nowacki J, Carnero Corrales MA, Wilke J, Laraia L, Tschapalda K, Metz M, Sehr DA, Brand S, Winklhofer KF, Janning P, Ziegler S, Waldmann H (2019) Synthesis of Indomorphan Pseudo-Natural Product Inhibitors of Glucose Transporters GLUT-1 and -3. Angew Chem Int Ed Engl. 58(47): 17016-17025 doi: 10.1002/anie.201909518

  • van Well EM, Bader V, Patra M, Sánchez-Vicente A, Meschede J, Furthmann N, Schnack C, Blusch A, Longworth J, Petrasch-Parwez E, Mori K, Arzberger T, Trümbach D, Angersbach L, Showkat C, Sehr DA, Berlemann LA, Goldmann P, Clement AM, Behl C, Woerner AC, Saft C, Wurst W, Haass C, Ellrichmann G, Gold R, Dittmar G, Hipp MS, Hartl FU, Tatzelt J, Winklhofer KF (2019) A protein quality control pathway regulated by linear ubiquitination. EMBO J. 38(9): e100730. doi: 10.15252/embj.2018100730

  • Ellrichmann G, Blusch A, Fatoba O, Brunner J, Reick C, Hayardeny L, Hayden M, Sehr D, Winklhofer KF, Saft C, Gold R (2019) Author Correction: Laquinimod treatment in the R6/2 mouse model. Sci Rep. 9(1): 4960. doi: 10.1038/s41598-018-37926-4

2018
  • Ulbrich S, Janning P, Seidel R, Matschke J, Gonsberg A, Jung S, Glatzel M, Engelhard M, Winklhofer KF, Tatzelt J (2018) Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease. PLoS One. 13(5): e0197659. doi: 10.1371/journal.pone.0197659

  • Engelke AD, Gonsberg A, Thapa S, Jung S, Ulbrich S, Seidel R, Basu S, Multhaup G, Baier M, Engelhard M, Schätzl HM, Winklhofer KF, Tatzelt J (2018) Dimerization of the cellular prion protein inhibits propagation of scrapie prions. J Biol Chem. 293(21): 8020-8031. doi: 10.1074/jbc.RA117.000990

  • Röderer P, Klatt L, John F, Theis V, Winklhofer KF, Theiss C, Matschke V (2018) Increased ROS Level in Spinal Cord of Wobbler Mice due to Nmnat2 Downregulation. Mol Neurobiol. 55(11): 8414-8424. doi: 10.1007/s12035-018-0999-7

  • Degrossoli A, Müller A, Xie K, Schneider JF, Bader V, Winklhofer KF, Meyer AJ, Leichert LI (2018) Neutrophil-generated HOCl leads to non-specific thiol oxidation in phagocytized bacteria. Elife 7. pii: e32288. doi: 10.7554/eLife.32288

2017
  • Gonsberg A, Jung S, Ulbrich S, Origi A, Ziska A, Baier M, Koch HG, Zimmermann R, Winklhofer KF, Tatzelt J. (2017) The Sec61/SecY complex is inherently deficient in translocating intrinsically disordered proteins. J Biol Chem. 292(52): 21383-21396. doi: 10.1074/jbc.M117.788067

  • Ellrichmann G, Blusch A, Fatoba O, Brunner J, Hayardeny L, Hayden M, Sehr D, Winklhofer KF, Saft C, Gold R (2017) Laquinimod treatment in the R6/2 mouse model. Sci Rep. 7(1): 4947. doi: 10.1038/s41598-017-04990-1

  • Menges S, Minakaki G, Schaefer PM, Meixner H, Prots I, Schlötzer-Schrehardt U, Friedland K, Winner B, Outeiro TF, Winklhofer KF, von Arnim CA, Xiang W, Winkler J, Klucken J (2017) Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress. Sci Rep. 7: 42942. doi: 10.1038/srep42942

  • Bruch J, Xu H, Rösler TW, De Andrade A, Kuhn PH, Lichtenthaler SF, Arzberger T, Winklhofer KF, Müller U, Höglinger GU (2017) PERK activation mitigates tau pathology in vitro and in vivo. EMBO Mol Med. 9(3): 371-384. doi: 10.15252/emmm.201606664

2016
  • Voigt A, Berlemann LA and Winklhofer KF (2016) The mitochondrial kinase PINK1: functions beyond mitophagy. J Neurochem. 139 Suppl 1: 232-239. doi: 10.1111/jnc.13655

  • Klionsky DJ et al.  (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12(1): 1-222. doi: 10.1080/15548627.2015.1100356

  • Woerner AC, Frottin F, Hornburg D, Feng LR, Meissner F, Patra M, Tatzelt J, Mann M, Winklhofer KF, Hartl FU and Hipp MS (2016) Cytoplasmic protein aggregates interfere with nucleo-cytoplasmic transport of protein and RNA. Science 351(6269): 173-176,. doi: 10.1126/science.aad2033

2015
  • Meka DP, Müller-Rischart AK, Nidadavolu P, Mohammadi B, Motori E, Ponna SK, Aboutalebi H, Bassal M, Annamneedi A, Finckh B, Miesbauer M, Rotermund N, Lohr C, Tatzelt J, Winklhofer KF, and Kramer ER (2015) Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration. J Clin Invest 125(5): 1873-1885. doi: 10.1172/JCI79300
2014
  • Winklhofer KF (2014) Parkin and mitochondrial quality control: Towards assembling the puzzle. Trends Cell Biol 24(6): 332-341. doi: 10.1016/j.tcb.2014.01.001

  • Klein P, Müller-Rischart AK, Motori E, Schönbauer C, Schnorrer F, Winklhofer KF and Klein R (2014) Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants. EMBO J 33(4): 341-355. doi: 10.1002/embj.201284290

2013
  • Motori E, Puyal J, Toni N, Ghanem A, Angeloni C, Malaguti M, Cantelli-Forti G, Berninger B, Conzelmann KK, Götz M, Winklhofer KF, Hrelia S and Bergami M (2013) Inflammation-Induced Alteration of Astrocyte Mitochondrial Dynamics Requires Autophagy for Mitochondrial Network Maintenance. Cell Metab (18)6: 844-859. doi: 10.1016/j.cmet.2013.11.005

  • Rolland SG, Motori E, Memar N, Hench J, Frank S, Winklhofer KF and Conradt B (2013) Impaired complex IV activity in response to loss of LRPPRC function can be compensated by mitochondrial hyperfusion. Proc Natl Acad Sci USA 110(32): E2967-E2976. doi: 10.1073/pnas.1303872110

  • Dirndorfer D, Seidel RP, Nimrod G, Miesbauer M, Ben-Tal N, Engelhard M, Zimmermann R, Winklhofer KF and Tatzelt J (2013) The α-helical structure of prodomains promotes translocation of intrinsically disordered neuropeptide hormones into the endoplasmic reticulum. J Biol Chem 288(20): 13961-13973. doi: 10.1074/jbc.M112.430264

  • Zhang L, Karsten P, Hamm S, Pogson JH, Müller-Rischart AK, Exner N, Haass C, Whitworth A, Winklhofer KF, Schulz JB and Voigt A (2013) TRAP1 rescues PINK1 loss-of-function phenotypes. Hum Mol Genet 22(14): 2829-2841. doi: 10.1093/hmg/ddt132

  • Pfeiffer NV, Dirndorfer D, Lang S, Miesbauer M, Zimmermann R, Winklhofer KF and Tatzelt J (2013) Structural features within the nascent chain regulate alternative targeting of secretory proteins to mitochondria. EMBO J 32(7): 1036-1051. doi: 10.1038/emboj.2013.46

  • Müller-Rischart AK, Pilsl A, Beaudette P, Hadian K, Deinlein A, Funke M, Patra M, Motori E, Schweimer C, Kuhn PH, Hrelia S, Lichtenthaler SF, Wurst W, Trümbach D, Langer T, Krappmann D, Dittmar G, Tatzelt, J and Winklhofer KF (2013) The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO. Mol Cell 49(5): 908-921. doi: 10.1016/j.molcel.2013.01.036

2012
  • Resenberger UK, Müller V, Munter LM, Baier M, Multhaup G, Wilson MR, Winklhofer KF, Tatzelt J. (2012) The heat shock response is modulated by and interferes with toxic effects of scrapie prion protein and amyloid β. J Biol Chem. 287(52): 43765-76. doi: 10.1074/jbc.M112.389007
  • Exner N, Lutz AK, Haass C, Winklhofer KF (2012) Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences. EMBO J. 31(14): 3038-62. doi: 10.1038/emboj.2012.170

  • Butler EK, Voigt A, Lutz AK, Toegel JP, Gerhardt E, Karsten P, Falkenburger B, Reinartz A, Winklhofer KF, Schulz JB. (2012) The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity. PLoS Genet. 8(2): e1002488. doi: 10.1371/journal.pgen.1002488

  • Resenberger UK, Winklhofer KF, Tatzelt J. (2012) Cellular prion protein mediates toxic signaling of amyloid beta. Neurodegener Dis. 10(1-4): 298-300. doi: 10.1159/000332596

  • Pilsl A, Winklhofer KF (2012) Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinson's disease. Acta Neuropathol. 123(2): 173-88. doi: 10.1007/s00401-011-0902-3

  • Glasl L, Kloos K, Giesert F, Roethig A, Di Benedetto B, Kühn R, Zhang J, Hafen U, Zerle J, Hofmann A, de Angelis MH, Winklhofer KF, Hölter SM, Vogt Weisenhorn DM, Wurst W. (2012) Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb. Exp Neurol. 2012 May;235(1):214-27. doi: 10.1016/j.expneurol.2012.01.002

2011
  • Resenberger UK, Winklhofer KF, Tatzelt J (2011) Neuroprotective and neurotoxic signaling by the prion protein. Top Curr Chem. 305: 101-19. doi: 10.1007/128_2011_160

  • Resenberger UK, Harmeier A, Woerner AC, Goodman JL, Müller V, Krishnan R, Vabulas RM, Kretzschmar HA, Lindquist S, Hartl FU, Multhaup G, Winklhofer KF, Tatzelt J (2011) The cellular prion protein mediates neurotoxic signaling of β-sheet-rich conformers independent of prion replication. EMBO J. 30(10): 2057-70. doi: 10.1038/emboj.2011.86

  • Sakthivelu V, Seidel RP, Winklhofer KF, Tatzelt J. (2011) Conserved stress-protective activity between prion protein and Shadoo. J Biol Chem. 286(11): 8901-8. doi: 10.1074/jbc.M110.185470

  • Bouman L, Schlierf A, Lutz AK, Shan J, Deinlein A, Kast J, Galehdar Z, Palmisano V, Patenge N, Berg D, Gasser T, Augustin R, Trümbach D, Irrcher I, Park DS, Wurst W, Kilberg MS, Tatzelt J, Winklhofer KF (2011) Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress. Cell Death Differ. 18(5): 769-82. doi: 10.1038/cdd.2010.142

2010
  • Chu NK, Olschewski D, Seidel R, Winklhofer KF, Tatzelt J, Engelhard M, Becker CF (2010) Protein immobilization on liposomes and lipid-coated nanoparticles by protein trans-splicing. J Pept Sci. 16(10): 582-8. doi: 10.1002/psc.1227

  • Kamp F, Exner N, Lutz AK, Wender N, Hegermann J, Brunner B, Nuscher B, Bartels T, Giese A, Beyer K, Eimer S, Winklhofer KF, Haass C (2010) Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1. EMBO J. 29(20): 3571-89. doi: 10.1038/emboj.2010.223

  • Fett ME, Pilsl A, Paquet D, van Bebber F, Haass C, Tatzelt J, Schmid B, Winklhofer KF (2010) Parkin is protective against proteotoxic stress in a transgenic zebrafish model. PLoS One. 5(7): e11783. doi: 10.1371/journal.pone.0011783

  • Irrcher I, Aleyasin H, Seifert EL, Hewitt SJ, Chhabra S, Phillips M, Lutz AK, Rousseaux MW, Bevilacqua L, Jahani-Asl A, Callaghan S, MacLaurin JG, Winklhofer KF, Rizzu P, Rippstein P, Kim RH, Chen CX, Fon EA, Slack RS, Harper ME, McBride HM, Mak TW, Park DS. (2010) Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics. Hum Mol Genet. 19(19): 3734-46. doi: 10.1093/hmg/ddq288

  • Schumacher MC, Resenberger U, Seidel RP, Becker CF, Winklhofer KF, Oesterhelt D, Tatzelt J, Engelhard M (2010) Synthesis of a GPI anchor module suitable for protein post-translational modification. Biopolymers. 94(4): 457-64. doi: 10.1002/bip.21380

  • Miesbauer M, Rambold AS, Winklhofer KF, Tatzelt J. (2010) Targeting of the prion protein to the cytosol: mechanisms and consequences. Curr Issues Mol Biol. 12(2): 109-18. PMID: 19767654

  • Winklhofer KF, Haass C. (2010) Mitochondrial dysfunction in Parkinson's disease. Biochim Biophys Acta. 1802(1): 29-44. doi: 10.1016/j.bbadis.2009.08.013

2009
  • Miesbauer M, Pfeiffer NV, Rambold AS, Müller V, Kiachopoulos S, Winklhofer KF, Tatzelt J (2009) alpha-Helical domains promote translocation of intrinsically disordered polypeptides into the endoplasmic reticulum. J Biol Chem. 284(36): 24384-93. doi: 10.1074/jbc.M109.023135

  • Lutz AK, Exner N, Fett ME, Schlehe JS, Kloos K, Lämmermann K, Brunner B, Kurz-Drexler A, Vogel F, Reichert AS, Bouman L, Vogt-Weisenhorn D, Wurst W, Tatzelt J, Haass C, Winklhofer KF (2009) Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. J Biol Chem 284(34): 22938-51. doi: 10.1074/jbc.M109.035774

2008
  • Rambold AS, Miesbauer M, Olschewski D, Seidel R, Riemer C, Smale L, Brumm L, Levy M, Gazit E, Oesterhelt D, Baier M, Becker CF, Engelhard M, Winklhofer KF, Tatzelt J (2008) Green tea extracts interfere with the stress-protective activity of PrP and the formation of PrP. J Neurochem. 107(1): 218-29. doi: 10.1111/j.1471-4159.2008.05611.x

  • Rambold AS, Müller V, Ron U, Ben-Tal N, Winklhofer KF, Tatzelt J. (2008) Stress-protective signalling of prion protein is corrupted by scrapie prions. EMBO J. 27(14): 1974-84. doi: 10.1038/emboj.2008.122

  • Schlehe JS, Lutz AK, Pilsl A, Lämmermann K, Grgur K, Henn IH, Tatzelt J, Winklhofer KF (2008) Aberrant folding of pathogenic Parkin mutants: aggregation versus degradation. J Biol Chem. 283(20): 13771-9. doi: 10.1074/jbc.M707494200

  • Winklhofer KF, Tatzelt J, Haass C (2008) The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases. EMBO J. 27(2): 336-49. doi: 10.1038/sj.emboj.7601930

  • Wegmann S, Miesbauer M, Winklhofer KF, Tatzelt J, Muller DJ (2008) Observing fibrillar assemblies on scrapie-infected cells. Pflugers Arch. 456(1): 83-93. doi: 10.1007/s00424-007-0433-x

2007
  • Winklhofer KF (2007) The parkin protein as a therapeutic target in Parkinson's disease. Expert Opin Ther Targets. 11(12): 1543-52. doi: 10.1517/14728222.11.12.1543

  • Exner N, Treske B, Paquet D, Holmström K, Schiesling C, Gispert S, Carballo-Carbajal I, Berg D, Hoepken HH, Gasser T, Krüger R, Winklhofer KF, Vogel F, Reichert AS, Auburger G, Kahle PJ, Schmid B, Haass C (2007) Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J Neurosci. 27(45): 12413-8. doi: 10.1523/jneurosci.0719-07.2007

  • Olschewski D, Seidel R, Miesbauer M, Rambold AS, Oesterhelt D, Winklhofer KF, Tatzelt J, Engelhard M, Becker CF (2007) Semisynthetic murine prion protein equipped with a GPI anchor mimic incorporates into cellular membranes. Chem Biol. 14(9): 994-1006. doi: 10.1016/j.chembiol.2007.08.007

  • Henn IH, Bouman L, Schlehe JS, Schlierf A, Schramm JE, Wegener E, Nakaso K, Culmsee C, Berninger B, Krappmann D, Tatzelt J, Winklhofer KF (2007) Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling. J Neurosci. 27(8): 1868-78. doi: 10.1523/jneurosci.5537-06.2007

2006
  • Winklhofer KF (2006) [Inactivation of parkin in Parkinson disease]. Pharm Unserer Zeit. 35(3): 186-7. doi: 10.1002/pauz.200690056

  • Rambold AS, Miesbauer M, Rapaport D, Bartke T, Baier M, Winklhofer KF, Tatzelt J (2006) Association of Bcl-2 with misfolded prion protein is linked to the toxic potential of cytosolic PrP. Mol Biol Cell. 17(8): 3356-68. doi: 10.1091/mbc.e06-01-0083

  • Winklhofer KF, Tatzelt J (2006) The role of chaperones in Parkinson's disease and prion diseases. Handb Exp Pharmacol. (172): 221-58. doi: 10.1007/3-540-29717-0_10

  • Hirschberger T, Stork M, Schropp B, Winklhofer KF, Tatzelt J, Tavan P (2006) Structural instability of the prion protein upon M205S/R mutations revealed by molecular dynamics simulations. Biophys J. 90(11): 3908-18. doi: 10.1529/biophysj.105.075341

  • Miesbauer M, Bamme T, Riemer C, Oidtmann B, Winklhofer KF, Baier M, Tatzelt J (2006) Prion protein-related proteins from zebrafish are complex glycosylated and contain a glycosylphosphatidylinositol anchor. Biochem Biophys Res Commun. 341(1): 218-24. doi: 10.1016/j.bbrc.2005.12.168

2005
  • Dumpitak C, Beekes M, Weinmann N, Metzger S, Winklhofer KF, Tatzelt J, Riesner D (2005) The polysaccharide scaffold of PrP 27-30 is a common compound of natural prions and consists of alpha-linked polyglucose. Biol Chem. 386(11): 1149-55. doi: 10.1515/BC.2005.131

  • Bertsch U, Winklhofer KF, Hirschberger T, Bieschke J, Weber P, Hartl FU, Tavan P, Tatzelt J, Kretzschmar HA, Giese A (2005) Systematic identification of antiprion drugs by high-throughput screening based on scanning for intensely fluorescent targets. J Virol. 79(12): 7785-91. doi: 10.1128/jvi.79.12.7785-7791.2005

  • Uelhoff A, Tatzelt J, Aguzzi A, Winklhofer KF, Haass C (2005) A pathogenic PrP mutation and doppel interfere with polarized sorting of the prion protein. J Biol Chem. 280(7): 5137-40. doi: 10.1074/jbc.C400560200

  • Henn IH, Gostner JM, Lackner P, Tatzelt J, Winklhofer KF (2005) Pathogenic mutations inactivate parkin by distinct mechanisms. J Neurochem. 92(1): 114-22. doi: 10.1111/j.1471-4159.2004.02854.x

  • Kiachopoulos S, Bracher A, Winklhofer KF, Tatzelt J (2005) Pathogenic mutations located in the hydrophobic core of the prion protein interfere with folding and attachment of the glycosylphosphatidylinositol anchor. J Biol Chem. 280(10): 9320-9. doi: 10.1074/jbc.M412525200

2004
  • Tatzelt J, Winklhofer KF (2004) Folding and misfolding of the prion protein in the secretory pathway. Amyloid. 11(3): 162-72. doi: 10.1080/1350-6120400000723

  • Kiachopoulos S, Heske J, Tatzelt J, Winklhofer KF (2004) Misfolding of the prion protein at the plasma membrane induces endocytosis, intracellular retention and degradation. Traffic. 5(6): 426-36. doi: 10.1111/j.1398-9219.2004.00185.x

  • Heske J, Heller U, Winklhofer KF, Tatzelt J (2004) The C-terminal globular domain of the prion protein is necessary and sufficient for import into the endoplasmic reticulum. J Biol Chem. 279(7): 5435-43. doi: 10.1074/jbc.M309570200

2003
  • Winklhofer KF, Henn IH, Kay-Jackson PC, Heller U, Tatzelt J (2003) Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones. J Biol Chem. 278(47): 47199-208. doi: 10.1074/jbc.M306769200

  • Brychzy A, Rein T, Winklhofer KF, Hartl FU, Young JC, Obermann WM (2003) Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. EMBO J. 22(14): 3613-23. doi: 10.1093/emboj/cdg362

  • Heller U, Winklhofer KF, Heske J, Reintjes A, Tatzelt J (2003) Post-translational import of the prion protein into the endoplasmic reticulum interferes with cell viability: a critical role for the putative transmembrane domain. J Biol Chem. 278(38): 36139-47. doi: 10.1074/jbc.M304002200

  • Winklhofer KF, Heller U, Reintjes A, Tatzelt J (2003) Inhibition of complex glycosylation increases the formation of PrPsc. Traffic. 4(5): 313-22. doi: 10.1034/j.1600-0854.2003.00088.x

  • Winklhofer KF, Heske J, Heller U, Reintjes A, Muranyi W, Moarefi I, Tatzelt J (2003) Determinants of the in vivo folding of the prion protein. A bipartite function of helix 1 in folding and aggregation. J Biol Chem. 278(17): 14961-70. doi: 10.1074/jbc.M209942200

2001
  • Winklhofer KF, Reintjes A, Hoener MC, Voellmy R, Tatzelt J (2001) Geldanamycin restores a defective heat shock response in vivo. J Biol Chem. 276(48): 45160-7. doi: 10.1074/jbc.M104873200

  • Winklhofer KF, Hartl FU, Tatzelt J (2001) A sensitive filter retention assay for the detection of PrP(Sc) and the screening of anti-prion compounds. FEBS Lett. 503(1): 41-5. doi: 10.1016/s0014-5793(01)02692-8

  • Gilch S, Winklhofer KF, Groschup MH, Nunziante M, Lucassen R, Spielhaupter C, Muranyi W, Riesner D, Tatzelt J, Schätzl HM (2001) Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease. EMBO J. 20(15): 3957-66. doi: 10.1093/emboj/20.15.3957

2000
  • Winklhofer KF, Albrecht I, Wegner M, Heilbronn R (2000) Human cytomegalovirus immediate-early gene 2 expression leads to JCV replication in nonpermissive cells via transcriptional activation of JCV T antigen. Virology. 275(2): 323-34. doi: 10.1006/viro.2000.0503

  • Winklhofer KF, Tatzelt J (2000) Cationic lipopolyamines induce degradation of PrPSc in scrapie-infected mouse neuroblastoma cells. Biol Chem. 381(5-6): 463-9. doi: 10.1515/BC.2000.061